Abstract
A family is presented in which the proposita, affected with thalassaemia major, developed a chronic leg ulcer at the age of 14 yr. Her eldest brother, not affected with thalassaemia, had a transient leg ulcer at the age of 18 yr and a 2nd brother, affected with thalassaemia minor, developed leg ulcers when aged 15 yr. All 3 siblings were G-6-P dehydrogenase deficient.

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