A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
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Open Access
- 10 June 2007
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 39 (7) , 827-829
- https://doi.org/10.1038/ng2058
Abstract
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding (rs13119723; P = 2.0 × 10−7) was in the KIAA1109-TENR-IL2-IL21 linkage disequilibrium block. We independently confirmed association in two further collections (strongest association at rs6822844, 24 kb 5′ of IL21; meta-analysis P = 1.3 × 10−14, odds ratio = 0.63), suggesting that genetic variation in this region predisposes to celiac disease.Keywords
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