Effects of Whole-Body and Partial-Body X Irradiation upon Epidermal Mitotic Activity during Wound Healing in Mouse Skin

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Abstract
Mitotic activity of normal (unwounded) and wounded skin was measured in the control (nonirradiated) and whole-body or partial-body X-irradiated mouse. Higher mitotic activity in the anterior than in the posterior region of the body was found in both the normal and wounded skin of the control mouse. Whole-body irradiation (500 R) depressed completely the mitotic activity of normal skin 2-4 days after irradiation. In spite of this depression in mitotic activity, a surgical incision made 1-3 days after irradiation could induce a burst of proliferation after an inhibition of an initial mitosis increase. When the animals were partially irradiated with 500 R 3 days before wounding, mitosis at 24 h after wounding was inhibited markedly by the local effect of irradiation. Mitosis also could be inhibited diversely by the abscopal effect of irradiation. Because of a close similarity of sequential mitotic patterns between whole-body-irradiated and flapped-skin-only-irradiated groups (direct irradiation), the effect of irradiation on mitosis was considered to be primarily local. Some discussions were made concerning the possible reasons which made a difference in mitotic patterns between the head-only-irradiated group, the irradiated group including the head and other parts of the body expect for the skin flap (abscopal irradiation).

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