Chromosomes of Primary Granulocytic Leukemia (Chloroleukemia) in the Rat

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Abstract
Chromosome studies were done on 9 rats with primary granulocytic leukemia (chloroleukemia) induced by gastric instillation of methylcholanthrene. Significant deviation from the normal diploid number (2n = 42) or from normal chromosome morphology was observed in only 1 rat whose leukemic cells showed at least 2 abnormal stemlines with 43 and 44 chromosomes. The other 8 rats with chloroleukemia and 3 with primary lymphocytic leukemia, similarly induced, did not show chromosome changes. A transplantable chloroleukemia, carried for 10 years, showed an apparently stable abnormal stemline with 43 chromosomes. It is concluded that there is no consistent or specific chromosome change associated with the primary methylcholanthrene-induced leukemias investigated.—J Nat Cancer Inst 30: 687–703, 1963.