The effects of tremorine and oxotremorine in hyperthyroid mice

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Abstract
Hyperthyroid mice exhibit only transient low-level tremor and hypothermia in response to tremorine and oxotremorine, yet the peripheral effects of these two agents are similar in intensity and duration to those elicited in control animals. These findings support the theory that tremor and hypothermia are both central effects and separate from the peripheral muscarinic actions of tremorine and oxotremorine. Of several possible explanations for the reduction in tremor and hypothermia, the most likely appears to be a potentiation of central adrenergic mechanisms in the hyperthyroid mice.