RNA-targeted therapeutics: prospects and promise
- 1 September 2002
- journal article
- Published by Informa Healthcare in Expert Opinion on Therapeutic Patents
- Vol. 12 (9) , 1367-1374
- https://doi.org/10.1517/13543776.12.9.1367
Abstract
Structured regions of viral, bacterial and human RNA are attractive targets for drug discovery. Interest is fuelled by the revelation, from nuclear magnetic resonance (NMR) and X-ray crystallography, that RNA has a structural complexity similar to proteins, and also by recent development of novel RNA-focused screening methods. However, few examples of RNA-targeted ligands have been reported to date. Analysis of these compounds, and their target specificity, suggests that considerable promise exists for the future development of new classes of therapeutic agents.Keywords
This publication has 32 references indexed in Scilit:
- Structure of the 30S ribosomal subunitNature, 2000
- Neomycin−Acridine Conjugate: A Potent Inhibitor of Rev-RRE BindingJournal of the American Chemical Society, 2000
- Stitching together RNA tertiary architecturesJournal of Molecular Biology, 1999
- Studying aminoglycoside antibiotic binding to HIV-1 TAR RNA by electrospray ionization mass spectrometryInternational Journal of Mass Spectrometry, 1999
- Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometryProceedings of the National Academy of Sciences, 1999
- Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitorsRNA, 1999
- Structural Motifs in RNAAnnual Review of Biochemistry, 1999
- Binding of Neomycin to the TAR Element of HIV-1 RNA Induces Dissociation of Tat Protein by an Allosteric MechanismBiochemistry, 1998
- Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNABiochimie, 1987
- Interaction of antibiotics with functional sites in 16S ribosomal RNANature, 1987