Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.
Open Access
- 15 December 1993
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 123 (6) , 1365-1371
- https://doi.org/10.1083/jcb.123.6.1365
Abstract
The cycle of nucleotide exchange and hydrolysis by a small GTP-binding protein, ADP-ribosylation factor (ARF), helps to provide vectoriality to vesicle transport. Coat assembly is triggered when ARF binds GTP, initiating transport vesicle budding, and coat disassembly is triggered when ARF hydrolyzes GTP, allowing the uncoated vesicle to fuse.Keywords
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