Two new insect growth regulator meliacins from Azadirachta indica A. Juss (meliaceae)

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Abstract
Two new bitter meliacins, nimocinolide (1) and isonimocinolide (2), have been isolated from the fresh leaves of Azadirachta indica(neem). A new meliacin, nimocin (6) has further been isolated from its fresh fruits along with the known azadirone, gedunin, epoxyazadiradione, 7-deacetyl-7-benzoylazadiradione, azadiradione, 17-hydroxyazadiradione, and β-sitosterol. The structures of these tetranortriterpenoids were elucidated through chemical and spectral studies. Compounds (1) and (2) acted as insect growth regulators against houseflies (Musca domestica) and mosquitoes (Aedes aegypti).