Growth Control in Cultured Mouse Fibroblasts: Induction of the Pleiotypic and Mitogenic Responses by a Purified Growth Factor
Open Access
- 1 July 1974
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (7) , 2600-2604
- https://doi.org/10.1073/pnas.71.7.2600
Abstract
Addition of serum to quiescent mouse fibroblasts induces a series of macromolecular changes (a pleiotypic response) followed by DNA synthesis and cell division. A new pituitary hormone, fibroblast growth factor, and hydrocortisone acting at physiological concentrations can completely replace exogenously added serum for the induction of these events in lines of BALB/c 3T3 cells. The induction of cell growth is specific for cultured fibroblasts; no stimulation is observed for mouse epithelial cells or virally transformed fibroblasts.Keywords
This publication has 21 references indexed in Scilit:
- Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growthNature, 1974
- Role of Insulin as a ‘Permissive’ Hormone in Mammary Gland DevelopmentNature, 1973
- Conditions Limiting Multiplication of Fibroblastic and Epithelial Cells in Dense CulturesNature, 1973
- Cyclic GMP and Cell MovementNature, 1973
- Epidermal Growth Factor: Receptors in Human Fibroblasts and Modulation of Action by Cholera ToxinProceedings of the National Academy of Sciences, 1973
- Serum Factor Requirements of Normal and Simian Virus 40-Transformed 3T3 Mouse FibroblastsProceedings of the National Academy of Sciences, 1971
- Topoinhibition and Serum Requirement of Transformed and Untransformed CellsNature, 1970
- Studies on carcinogenesis by avian sarcoma viruses. VI. Differential multiplication of uninfected and of converted cells in response to insulinJournal of Cellular Physiology, 1967
- The initiation of cell division in a contact‐inhibited mammalian cell lineJournal of Cellular and Comparative Physiology, 1965
- CONTACT INHIBITION, MACROMOLECULAR SYNTHESIS, AND POLYRIBOSOMES IN CULTURED HUMAN DIPLOID FIBROBLASTSProceedings of the National Academy of Sciences, 1965