THE ADRENAL ASCORBIC ACID-DEPLETING CAPACITY OF EXTRACTS OF THE INFANT RAT PITUITARY GLAND

1 March 1955

journal article
research article
Published by The Endocrine Society in Endocrinology

Vol. 56 (3) , 341-344
https://doi.org/10.1210/endo-56-3-341

Abstract

Dilute acid extracts of lyophilized pituitary tissue obtained from rats of the Long-Evans and Wistar strains, 4 through 7 days old, were able to deplete the adrenal ascorbic acid content of hypophysectomized, male, Sprague-Dawley rats, 125-150 g in weight. A qualitatively similar response was observed when such extracts were injected intr-peritoneally into 4 through 7 day old rats of the Long-Evans and Wistar strains. Comparative assays against the U.S.P. standard corticotropin indicate a concentration of the adrenal ascorbic acid-depleting moiety equivalent to about 3 milliunits (U.S.P.) in the average pituitary gland of rats from this age group.

Keywords

This publication has 1 reference indexed in Scilit:

THE MATURATION OF THE PITUITARY-ADRENAL AXIS IN THE NEWBORN RAT¹
Endocrinology, 1950