Studies of antigens inPlasmodium yoelii

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Abstract
Summary: Antigens of three lines of the rodent malaria parasitePlasmodium yoeliihave been studied using crossed immunoelectrophoresis.P. y. yoeliiline A1is a mild line which is restricted to reticulocytes.P. y. yoeliiline YM andP. y. nigeriensisline D1are virulent infections which multiply in both immature and mature erythrocytes. One antigen, designated Py-1, was found to differ in its electrophoretic mobility between the lines, being fast (F) in lines A1and YM and slow (S) in line D1. Antigen Py-1 also varied in quantity among the three lines; greater amounts were detected in parasites inhabiting mature erythrocytes than in those in reticulocytes. These characters were stable during blood and mosquito passage.