Antigenic Diversity in the Human Malaria Parasite Plasmodium falciparum
- 16 July 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 217 (4556) , 254-257
- https://doi.org/10.1126/science.6178159
Abstract
Monoclonal antibodies against blood forms of Plasmodium falciparum were used to demonstrate considerable antigenic diversity in this species. Different isolates were distinguished by their ability to react with certain antibodies, and most of the antibodies reacted specifically with merozoites, schizonts, or both. The distribution of different antigenic types appeared not to be related to geographic origin. Serological typing with monoclonal antibodies extends the range of methods for identification of different strains of this malaria parasite.Keywords
This publication has 12 references indexed in Scilit:
- Immunization against blood-stage rodent malaria using purified parasite antigensNature, 1981
- Cloning of Naturally Occurring Mixed Infections of Malaria ParasitesScience, 1981
- Enzyme typing of Plasmodium falciparum from African and some other Old World countriesTransactions of the Royal Society of Tropical Medicine and Hygiene, 1981
- Inhibition of P. falciparum growth in human erythrocytes by monoclonal antibodiesNature, 1981
- Serotyping Plasmodium falciparum malaria with S-antigensNature, 1980
- Protective monoclonal antibodies recognising stage-specific merozoite antigens of a rodent malaria parasiteNature, 1980
- Method to test inhibitory antibodies in human sera to wild populations of Plasmodium falciparumNature, 1976
- Human Malaria Parasites in Continuous CultureScience, 1976
- The distribution of enzyme variation in populations of Plasmodium falciparum in AfricaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1975
- A merozoite vaccine effective against Plasmodium knowlesi malariaNature, 1974