gp91phox-Containing NADPH Oxidase Mediates Endothelial Dysfunction in Renovascular Hypertension
- 13 April 2004
- journal article
- Published by Wolters Kluwer Health in Circulation
- Vol. 109 (14) , 1795-1801
- https://doi.org/10.1161/01.cir.0000124223.00113.a4
Abstract
Background— Isoforms of the NADPH oxidase contribute to vascular superoxide anion ( · O2−) formation and limit NO bioavailability. We hypothesized that the endothelial gp91phox-containing NADPH oxidase is predominant in generating the O2− to scavenge endothelial NO and thus is responsible for the development of endothelial dysfunction.Keywords
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