Highly Enantioselective Amination of α-Substituted α-Cyanoacetates with Chiral Catalysts Accessible from Both Quinine and Quinidine
- 22 December 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (2) , 167-169
- https://doi.org/10.1021/ol048190w
Abstract
The catalytic construction of nitrogen-substituted quaternary stereocenters is an important and challenging task in asymmetric synthesis. In this paper, we describe the use of 6‘-OH-modified cinchona alkaloids that are accessible from either quinine or quinidine for the development of a highly enantioselective amination of α,α-disubstituted carbonyl compounds that is suitable for the creation of nitrogen-substituted quaternary stereocenters in either the R or S configuration.Keywords
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