MICROSOMAL N-HYDROXYLATION OF TRANS-4'-ALKOXY-4-ACETAMIDOSTILBENES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 6  (3) , 226-231
Abstract
Hamster liver microsomes catalyze the N-hydroxylation of the 4''-OCH3, 4''-OCH2CH3, 4''-O(CH2)2CH3, and 4''-O(CH2)3CH3 analogs of the carcinogen trans-4-acetamidostilbene. Other metabolites which were identified were the O-deethylation product of the 4''-OCH2CH3 analog as well as the .alpha.,.beta.-epoxides of the 4''-OCH2CH3 and 4''-O(CH2)2CH3 compounds and the (.omega.-1)-hydroxylation product of trans-4''-n-butoxy-4-acetamidostilbene. The kinetics of metabolism of the 4''-O(CH2)3CH3 analog were determined, but the rates of formation of the metabolites of other members of the series were not linearly related to substrate concentration.