The spondylitis of inflammatory bowel disease

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Abstract
Of 12 patients with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) or sacroilitis (SI), only 4 (33%) had HLA‐B27. Family studies revealed 3 B27‐ negative relatives with AS, 1 with SI, 1 with SI and IBD, and 1 with IBD alone. HLA haplotypes did not segregate with disease. These data suggest a non‐HLA linked genetic predisposition to IBD which also confers susceptiblity to spondylitis, even in the absence of expression of bowel disease.