The Effects of Surgical Trauma on Human Granulopoiesis

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Abstract
Marked changes in the concentration and proliferative state of circulating granulocytic progenitor cells (colony forming units in culture; CFUc) were observed in female patients following surgical trauma. Within 1 day of an abdominal hysterectomy there was an abrupt fall in number of blood CFUc to between 10-20% of normal and an increase in the proportion synthesizing DNA which coincided with the maximum neutrophilia. As the neutrophil count declined, the CFUc concentration increased to supranormal values and the proliferative response persisted, both parameters returning to normal 2 wk after surgery. Following surgical trauma, the increased demand for neutrophils is apparently rapidly met by increased CFUc proliferation.