Heterogeneity of KCl-solubilized Antigens of Chemically Induced Sarcomas

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Abstract
Solubilized antigens of murine methylcholanthrene-induced fibrosarcomas prepared by treatment of tumor tissue with hypertonic KCl were separated into fractions depending upon exclusion by MW by selected ultra-filters. Material of high MW (> 300,000) and low MW (< 30,000) inhibited 3H-thymidine incorporation by lymphoid cells taken from tumor-bearing animals. When the inhibitor was removed, the material remaining stimulated proliferation in such lymphoid cells over a wide range of MW (< 30,000 daltons to > 100,000 daltons).