Simultaneous Quantitative Measurement of 131I‐Iodine and 99mTc‐Pertechnetate Uptake by Human Salivary Glands Using Scintiscanning with Validation by Direct Estimation in Biopsy Samples

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Abstract
131I‐iodide and 99Tc‐pertechnetate concentration in human salivary glands has been measured simultaneously in vivo by quantitative scintiscanning in 7 thyrotoxic subjects. The mid scan times were 5, 12 and 20 min. and the gland to plasma ratio (G/P) of 131I rose to 4.03±0.82 (s.e.) in the parotid and 10.7 ±3.1 (s.e.) in the submandibular glands. Corresponding values for G/P 99mTcO4‐were 2.70 ±0.34 in the parotid and 5.3 ± 1.2 in the submandibular glands. Values obtained at parotidectomy 1 h after intravenous administration of a mixture containing 125I‐ and 99mTcO4‐ to 6 patients were 4.13 ± 0.85 for G/P 125I‐ and 2.50 ± 0.62 for G/P99mTcO4‐. G/P131I‐ (or G/P125I‐) and G/P 99mTeO4‐, derived by both methods, were significantly correlated in parotid and submandibular glands. There was a significant correlation between G/P 131I‐/G/P 99mTcO4‐ in the parotid glands and G/P131I‐/G/P99mTcO4‐ in the submandibular glands. ‐It is concluded that 1. salivary gland values of 131I‐ and 99mTcO4,‐as measured by scintiscanning are very close to values obtained by direct counting of excised human salivary gland tissue and 2. that the secretion processes in both glands are physiologically related.
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