Effect of carbamate thioester derivatives of methyl- and 2-chloroethyl isocyanate on glutathione levels and glutathione reductase activity in isolated rat hepatocytes
- 3 August 1994
- journal article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 48 (3) , 587-594
- https://doi.org/10.1016/0006-2952(94)90290-9
Abstract
No abstract availableKeywords
This publication has 25 references indexed in Scilit:
- Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanateBiochemical Pharmacology, 1994
- Glutathione and N-acetylcysteine conjugates of 2-chloroethyl isocyanate. Identification as metabolites of N,N'-bis(2-chloroethyl)-N-nitrosourea in the rat and inhibitory properties toward glutathione reductase in vitroChemical Research in Toxicology, 1993
- Toxicity of the methyl isocyanate metabolite S-(N-methylcarbamoyl)GSH on mouse embryos in cultureTeratology, 1992
- Glutathione: a vehicle for the transport of chemically reactive metabolites in vivoAccounts of Chemical Research, 1991
- Carbamoylation of peptides and proteins in vitro by S-(N-methylcarbamoyl)glutathione and S-(N-methylcarbamoyl)cysteine, two electrophilic S-linked conjugates of methyl isocyanateChemical Research in Toxicology, 1991
- Biotransformation of methyl isocyanate in the rat. Evidence for glutathione conjugation as a major pathway of metabolism and implications for isocyanate-mediated toxicitiesChemical Research in Toxicology, 1991
- Chemical synthesis and cytotoxic properties of N-alkylcarbamic acid thioesters, metabolites of hepatotoxic formamidesChemical Research in Toxicology, 1990
- S-(N-Methylcarbamoyl)glutathione: A reactive S-linked metabolite of methyl isocyanateBiochemical and Biophysical Research Communications, 1990
- Tumor cell anti-oxidant defenses. Inhibition of the glutathione redox cycle enhances macrophage-mediated cytolysisThe Journal of Experimental Medicine, 1981
- [4] Isolation and use of liver cellsPublished by Elsevier ,1978