Studies on a new aminoglycoside antibiotic, dactimicin II. Isolation, structure and chemical degradation.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (9) , 1090-1100
- https://doi.org/10.7164/antibiotics.34.1090
Abstract
A new aminoglycoside antibiotic, dactimicin, produced by a Dactylosporangium matsuzakiense SF-2052, was isolated by column chromatography on a cation-exchange resin and CM-Sephadex. The structure of dactimicin was determined to be 4-amino-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-.beta.-L-lyxo-heptopyranosyl)-1-[(N-formimidoylglycyl)-methylamino]-6-O-methyl-L-chiro-inositol. Alkaline hydrolysis of dactimicin afforded 1-N-(N-formylglycyl)fortimicin B, fortimicin B, fortimicin A and an acyl migration product, 2''-N-(N-formylglycyl)fortimicin B.This publication has 4 references indexed in Scilit:
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- Studies on a new aminoglycoside antibiotic, dactimicin. I. Producing organism and fermentation.The Journal of Antibiotics, 1980
- A new broad-spectrum aminoglycoside antibiotic complex, sporaricin. III. The structures of sporaricins A and B.The Journal of Antibiotics, 1979
- Fortimicins A and B, new aminoglycoside antibiotics. III. Structural identification.The Journal of Antibiotics, 1977