Production of Antibodies to Papovavirus SV40 Tumor Antigen in African Green Monkeys.

Publisher Website
Google Scholar
Abstract
African green monkeys repeatedly inoculated with intact simian cells infected with simian papovavirus SV40 or with disrupted infected cells developed complement-fixing antibodies capable of reacting with the virus tumor and virus capsid antigens. The antibody against the tumor antigen appeared first and titers could be maintained or increased by reimmunization of the animals. In addition, virus-neutralizing antibodies were detected. These results demonstrate that antibody against the tumor antigen of the simian papovavirus, an antibody with the same specificity as that which appears in tumor-bearing hamsters, can be elicited in primates in the absence of detectable tumors.