THYROXINE EXCRETION, A POSSIBLE CAUSE OF GOITER

Abstract
Rats injected with 1-2 ug of I131 thyroxine excreted thyroxine at rates dependent upon their diets. Soy flour and laboratory chow caused thyroxine excretion rates which were 2 to 20 times greater than control diets. This mechanism may function to increase the iodide requirements of rats and may sometimes account for a "thyroxine depletion goiter.".