THE INFLUENCE OF SODIUM CHLORIDE CONCENTRATION ON THE IN VITRO OXYGEN CONSUMPTION OF RAT DIAPHRAGM, IN THE PRESENCE AND ABSENCE OF RED BLOOD CELLS

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Abstract
The influence of the conc. of NaCl in the blood plasma upon O2 consumption, previously demonstrated in living animals, is paralleled in vitro. The in vitro demonstration is possible only when the conditions more closely approximate the physiological than they ordinarily do. The effect is not apparent when tests are made in the absence of erythrocytes or Hb, and when the gas phase is 100% O2. It is readily demonstrable in the presence of erythrocytes or Hb, and when the gas phase is air. Substituting O2 for air in the latter case abolishes the effect. The NaCl acts both in vivo and in vitro (under physiological conditions), by influencing the rate of dissociation of oxygen and Hb, and thus affecting the amt. of O2 available for use by the tissues.

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