Small GTPase-regulated phospholipase D in granulocytes
- 1 July 1996
- journal article
- review article
- Published by Canadian Science Publishing in Biochemistry and Cell Biology
- Vol. 74 (4) , 459-467
- https://doi.org/10.1139/o96-050
Abstract
This review examines the functional role of phospholipase D in the neutrophil. Phospholipase D is emerging as an important component in the signal transduction pathways leading to granulocyte activation. Through the second messenger it produces, phosphatidic acid, phospholipase D plays an active role in the regulation of granulocyte NADPH oxidase activation and granular secretion. Many factors from both the cytosol and the membrane are necessary for maximal phospholipase D activation. This paper will focus on the regulation of phospholipase D by low molecular weight GTP-binding proteins, tyrosine kinases, and protein kinase C.Key words: phospholipase D, low molecular weight GTP-binding proteins, tyrosine kinases, protein kinase C, granulocytes.Keywords
This publication has 74 references indexed in Scilit:
- Synergistic Activation of Rat Brain Phospholipase D by ADP-ribosylation Factor and rhoA p21, and Its Inhibition by Clostridium botulinum C3 ExoenzymePublished by Elsevier ,1995
- Redistribution of Protein Kinase C Isoforms in Human Neutrophils Stimulated by Formyl Peptides and Phorbol-Myristate AcetateBiochemical and Biophysical Research Communications, 1995
- Potential Role of Protein Phosphorylation in GTP-γ-S-Dependent Activation of Phospholipase DBiochemical and Biophysical Research Communications, 1995
- C-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophilsBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1992
- ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding proteinCell, 1991
- Phospholipase D-catalyzed hydrolysis of phosphatidylcholine occurs with PO bond cleavageBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991
- Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factorBiochemical and Biophysical Research Communications, 1991
- The GTPase superfamily: conserved structure and molecular mechanismNature, 1991
- Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophilsBiochemical and Biophysical Research Communications, 1990
- Phospholipase D activation by the mitogens platelet‐derived growth factor and 12‐O‐tetradecanoylphorbol 13‐acetate in NIH‐3T3 cellsFEBS Letters, 1989