Sequence selective binding of ditrisarubicin B to DNA: comparison with daunomycin
- 3 July 1989
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 250 (2) , 323-327
- https://doi.org/10.1016/0014-5793(89)80747-1
Abstract
DNase I footprinting has been used to examine the sequence selective binding of ditrisarubicin B, novel anthracycline antibiotic, to DNA. At 37°C no footprinting pattern is observed, the drug protects all sites from enzymic cleavage with equal efficiency. At 4°C a footprinting pattern is induced with low drug concentrations which is different from that produced by daunomycin. The best binding sites contain the dinucleotide step GpT (ApC) and are located in regions of alternating purines and pyrimidines.Keywords
This publication has 8 references indexed in Scilit:
- Strong binding of ditrisarubicin B to DNA.The Journal of Antibiotics, 1988
- Site and sequence specificity of the daunomycin-DNA interactionBiochemistry, 1987
- Footprinting at low temperatures: evidence that ethidium and other simple intercalators can discriminate between different nucleotide sequencesNucleic Acids Research, 1987
- Nucleotide sequence binding preferences of nogalamycin investigated by DNase I footprintingBiochemistry, 1986
- A Theoretical Investigation on the Sequence Selective Binding of Daunomycin to Double-Stranded PolynucleotidesJournal of Biomolecular Structure and Dynamics, 1985
- New antitumor antibiotics, ditrisarubicins A, B and C.The Journal of Antibiotics, 1983
- Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG).Proceedings of the National Academy of Sciences, 1980
- Characterization of two xenopus somatic 5S DNAs and one minor oocyte-specific 5S DNACell, 1980