Difference in Treatment Outcome in Outpatients With Anxious Versus Nonanxious Depression: A STAR*D Report
Top Cited Papers
- 1 March 2008
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 165 (3) , 342-351
- https://doi.org/10.1176/appi.ajp.2007.06111868
Abstract
Objective: About half of outpatients with major depressive disorder also have clinically meaningful levels of anxiety. The authors conducted a secondary data analysis to compare antidepressant treatment outcomes for patients with anxious and nonanxious major depression in Levels 1 and 2 of the STAR*D study. Method: A total of 2,876 adult outpatients with major depressive disorder, enrolled from 18 primary and 23 psychiatric care sites, received citalopram in Level 1 of STAR*D. In Level 2, a total of 1,292 patients who did not remit with or tolerate citalopram were randomly assigned either to switch to sustained-release bupropion (N=239), sertraline (N=238), or extended-release venlafaxine (N=250) or to continue taking citalopram and receive augmentation with sustained-release bupropion (N=279) or buspirone (N=286). Treatment could last up to 14 weeks in each level. Patients were designated as having anxious depression if their anxiety/somatization factor score from the 17-item Hamilton Depression Rating S...Keywords
This publication has 35 references indexed in Scilit:
- An Evaluation of the Quick Inventory of Depressive Symptomatology and the Hamilton Rating Scale for Depression: A Sequenced Treatment Alternatives to Relieve Depression Trial ReportBiological Psychiatry, 2005
- Suicide risk management for the sequenced treatment alternatives to relieve depression study: applied NIMH guidelinesJournal of Psychiatric Research, 2004
- Achieving remission with venlafaxine and fluoxetine in major depression: its relationship to anxiety symptomsDepression and Anxiety, 2002
- Psychosocial and clinical predictors of unipolar depression outcome in older adultsInternational Journal of Geriatric Psychiatry, 2002
- A Self-Report Scale to Help Make Psychiatric DiagnosesArchives of General Psychiatry, 2001
- Effect of concurrent anxiety on response to sertraline and imipramine in patients with chronic depressionDepression and Anxiety, 2001
- The Inventory of Depressive Symptomatology (IDS): Clinician (IDS‐C) and Self‐Report (IDS‐SR) ratings of depressive symptomsInternational Journal of Methods in Psychiatric Research, 2000
- Rating chronic medical illness burden in geropsychiatric practice and research: Application of the Cumulative Illness Rating ScalePsychiatry Research, 1992
- Anxious depressions: Clinical, family history, and naturalistic outcome — comparisons with panic and major depressive disordersJournal of Affective Disorders, 1984
- The Nosologic Validity of Paranoia (Simple Delusional Disorder)Archives of General Psychiatry, 1980