HLA profile of the Mexican Mestizo population

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Abstract
The HLA-A, B and C profile of 665 Mexican Mestizos was studied by microcytotoxicity testing for 30 HLA specificities. Antigen, gene and haplotype frequencies were calculated, and results were compared to those of the 3 other series of HLA profiles in Mexican Mestizos available in the literature: 1 from Mexico-City, 1 from Los Angeles, California, USA, and a recent 1 from San Antonio, Texas, USA. Comparing the antigen frequencies of this series with those of the other study from Mexico-City, significant differences were only found in 3 antigens of the HLA-B locus. Comparison of either series from Mexico-City with the Los Angeles or the San Antonio studies yielded discrepancies in several specificities of both HLA-A and B loci, most notably the consistent absence of A25 in Mexican Mestizos living in Mexico City. The presence of this specificity in the Mexican Mestizo Population living in these 2 American cities could have resulted from input of Caucasian and black genes over several generations. Differences in haplotype frequency were observed comparing the 2 series from Mexico City and the series from San Antonio. Comparison of haplotype frequency with the Los Angeles series was not possible.