Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens

1 December 1976

journal article
research article
Published by Springer Nature in Nature

Vol. 264 (5588) , 722-727
https://doi.org/10.1038/264722a0

Abstract

The chemical induction of malignant transformation by nitrosomethylurea and 4-nitroquinoline-1-1 oxide in BHK [baby hamster kidney] cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature restricted phenotypes indicative of an altered gene product.

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