Matrix-degrading proteases in hormone-dependent breast cancer
- 1 January 1994
- journal article
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 31 (2-3) , 167-173
- https://doi.org/10.1007/bf00666150
Abstract
Proteases have emerged as important modulators of the metastatic capacity of cancer. However, metastasis is regulated by multiple other characteristics of the tumor cell and evidence suggests the participation of multiple classes of proteases. In the present article we review the literature concerning the potential biological roles of multiple proteases in breast cancer. In particular, we focus on the gelatin-degrading metallo proteinase and on a novel 80 KDa matrix-degrading protease that appears to be commonly expressed in hormone dependent breast cancer cell lines.Keywords
This publication has 30 references indexed in Scilit:
- Oncogene-induced basement membrane invasiveness in human mammary epithelial cellsClinical & Experimental Metastasis, 1994
- Tumor Cell Interactions with the Extracellular Matrix During Invasion and MetastasisAnnual Review of Cell Biology, 1993
- Type IV collagenases in invasive tumorsBreast Cancer Research and Treatment, 1993
- AbstractsBreast Cancer Research and Treatment, 1991
- Ras levels and metalloproteinase activity in normal versus neoplastic rat mammary tissuesClinical & Experimental Metastasis, 1991
- A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomasNature, 1990
- Growth factors specifically alter hair follicle cell proliferation and collagenolytic activity alone or in combinationDifferentiation, 1990
- Cathepsin D in breast cancerBreast Cancer Research and Treatment, 1990
- Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.The Journal of cell biology, 1989
- Structure, function, regulation and clinical significance of the 52K pro-cathepsin D secreted by breast cancer cellsBiochimie, 1988