Adoration of the Vagi?
- 16 August 1984
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 311 (7) , 463-464
- https://doi.org/10.1056/nejm198408163110709
Abstract
The use of muscarinic antagonists, such as atropine, as bronchodilators has captured the interest of investigators studying the regulation of airway smooth muscle. Cyclic anticholinergic compounds that have recently been developed can be delivered by aerosols into the airways, with minimal systemic side effects. Thus, if acctylcholine released from vagal motor nerves innervating airway smooth muscle is an important cause of airway narrowing in disease, substantial bronchodilation may result, possibly with few side effects (i.e., a high "therapeutic ratio"). For these reasons, it is important therapeutically to determine the efficacy and limitations of the use of muscarinic antagonists.Evidence for . . .Keywords
This publication has 3 references indexed in Scilit:
- Role of the Parasympathetic System in Airway Obstruction Due to EmphysemaNew England Journal of Medicine, 1984
- Selective generation of leukotriene B4 by tracheal epithelial cells from dogsBiochemical and Biophysical Research Communications, 1983
- A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pigProceedings of the National Academy of Sciences, 1983