Acute Changes in Blood Glucose Concentration do not Promote Thrombin Generation or Fibrin Breakdown in Type 1 Diabetes

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Abstract
To investigate the effect of blood glucose concentration on thrombin generation and fibrinolytic activity, six Type 1 patients had the blood glucose concentration maintained for 1 h at 5, 15, and 25 mmol l−1, and 8 patients underwent hypoglycaemia of 20 min duration after the blood glucose had been kept at 8 mmol l−1 for 1 h. During hyperglycaemia plasminogen activator activity rose from 214 (11–625) (median, range) to 478 (18–772) units (p < 0.05) at a blood glucose of 5 mmol l−1 and to 511 (89–816) (p < 0.05) and 535 (33–976) (p < 0.05) units at a blood glucose of 15 and 25 mmol l−1, respectively. Cross‐linked fibrin degradation products (FDP) were 45 and 53 μg l−1 at a blood glucose of 5 mmol l−1 and remained unchanged at higher glucose levels. Fibrinopeptide A was 1.3 (0.6‐2.8) nmol l−1 at a blood glucose of 5 mmol l−1, and remained unchanged with hyperglycaemia, being 1.3 (0.9‐1.3) nmol l−1 after 1 h at 25 mmol l−1. During hypoglycaemia, plasminogen activator activity rose from 155 to 745 units (p < 0.05) while both fibrinopeptide A and cross‐linked FDP remained unchanged. The results indicate that acute fluctuations in blood glucose concentration do not lead to thrombin generation. Additionally, increased fibrinolytic activity measured in vitro is not associated with an increase in cross‐linked FDP. This suggests that short‐term hyper‐ and hypoglycaemia do not affect the end‐products of the coagulation and fibrinolytic pathways.