EFFECT OF 2‐MERCAPTOETHANOL ON THE MIXED LEUKOCYTE REACTION IN MAN

Publisher Website
Google Scholar
Abstract
When 2‐mercaptoethanol (2‐ME) is added to human mixed leukocyte cultures at the beginning of the culture period, only a very weak effect is seen. When 2‐ME is added after a few days' culture, a marked enhancement of cellular transformation occurs. 2‐ME can also enhance the effect of blastogenic factor (BF) containing media and it is possible that this effect depends on a stabilization or protection of BF preventing the break‐down of BF in cellular systems.