Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease
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Open Access
- 1 January 2010
- journal article
- review article
- Published by Springer Nature in Alzheimer's Research & Therapy
- Vol. 3 (1) , 1-13
- https://doi.org/10.1186/alzrt59
Abstract
Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.Keywords
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