Molecular Characterization of G-protein Coupled Receptors: Isolation and Cloning of a D1 Dopamine Receptor
- 1 January 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Receptor Research
- Vol. 11 (1-4) , 521-534
- https://doi.org/10.3109/10799899109066425
Abstract
This article summarizes the recent progress our laboratory has made in understanding the molecular characteristics of the D1 dopamine receptor. The D1 dopamine receptor from rat striatum has been purified to near homogeneity using a combination of several chromatographic steps. Furthermore, the gene for the human D1 dopamine receptor has been cloned, sequenced, and expressed. The cloned receptor has all the pharmacologic and biochemical properties of the classical D1 receptor coupled to adenylyl cyclase which has been previously described in the central nervous system.Keywords
This publication has 26 references indexed in Scilit:
- Structure of the Adrenergic and Related ReceptorsAnnual Review of Neuroscience, 1989
- Cloning and expression of a rat D2 dopamine receptor cDNANature, 1988
- An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteinsNature, 1987
- Identification of a Family of Muscarinic Acetylcholine Receptor GenesScience, 1987
- A family of receptors coupled to guanine nucleotide regulatory proteinsBiochemistry, 1987
- Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequenceFEBS Letters, 1986
- Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptorNature, 1986
- The avian beta-adrenergic receptor: primary structure and membrane topology.Proceedings of the National Academy of Sciences, 1986
- Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsinNature, 1986
- Mammalian .beta.2-adrenergic receptor: purification and characterizationBiochemistry, 1984