Testosterone in Human Plasma

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Abstract
TESTOSTERONE is the most potent of naturally occurring androgens, but attempts to measure testosterone in human peripheral venous plasma by standard chemical technics have generally been unsuccessful.1 This lack of success has been thought to be due to low circulating concentration of testosterone. The concentration of the free hormone in peripheral plasma appears to reflect more nearly the quantity available for tissue activity than the amount of hormone in urine or other body fluids. The majority of the 17-ketosteroids found in urine are the metabolic products of other less potent androgens than testosterone, and their measurement is a nearly useless . . .

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