In vitroandin vivomodels for testing arrhythmogenesis in drugs
- 29 November 2005
- journal article
- review article
- Published by Wiley in Journal of Internal Medicine
- Vol. 259 (1) , 70-80
- https://doi.org/10.1111/j.1365-2796.2005.01590.x
Abstract
: The steadily increasing list of drugs associated with prolongation of the QT interval and torsades de pointes (TdP) constitute a medical problem of major concern. Hence, there is a need at an early stage to identify drug candidates with an inherent capacity to induce repolarization‐related proarrhythmias, avoiding exposure of large populations to potentially harmful drugs. Furthermore, the availability of clinically relevant and predictive animal models should reduce the risk that effective and potentially life‐saving drugs never reach the market. This review will discuss the pros and cons of somein vivoandin vitroanimal models for assessing proarrhythmia liability.Keywords
This publication has 41 references indexed in Scilit:
- Assessment of the Proarrhythmic Potential of the Novel Antiarrhythmic Agent AZD7009 and Dofetilide in Experimental Models of Torsades De PointesJournal of Cardiovascular Electrophysiology, 2005
- Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamilJournal of the American College of Cardiology, 2005
- Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: The role of experimental modelsJournal of Electrocardiology, 2004
- Assessing predictors of drug-induced torsade de pointesTrends in Pharmacological Sciences, 2003
- Cisapride-Induced Transmural Dispersion of Repolarization and Torsade de Pointes in the Canine Left Ventricular Wedge Preparation During Epicardial StimulationCirculation, 2003
- Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug developmentPublished by Oxford University Press (OUP) ,2003
- Phase 2 Early Afterdepolarization as a Trigger of Polymorphic Ventricular Tachycardia in Acquired Long-QT SyndromeCirculation, 2001
- Characteristics and Distribution of M Cells in Arterially Perfused Canine Left Ventricular Wedge PreparationsCirculation, 1998
- Cellular Basis for the Normal T Wave and the Electrocardiographic Manifestations of the Long-QT SyndromeCirculation, 1998
- Sodium Channel Block With Mexiletine Is Effective in Reducing Dispersion of Repolarization and Preventing Torsade de Pointes in LQT2 and LQT3 Models of the Long-QT SyndromeCirculation, 1997