Hypertension Produced by Chemical Renal Medullectomy: Evidence for a Renomedullary Vasodepressor Function in the Rat

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Abstract
The rat renal papilla was selectively destroyed by 2-bromoethylamine hydrobromide; increasing doses produced a graded severity of histological damage, polyuria and a reduction in urinary prostaglandin E2 excretion. Destruction of at least half of the papilla caused significant hypertension, but plasma renin concentration and plasma creatinine did not change. After graded medullary damage Goldblatt 2-kidney, 1-clip hypertension was induced. Four weeks later the severity of hypertension was similar in medulla-damaged and medulla-intact groups. When Goldblatt 2-kidney, 1-clip hypertension was reversed by removal of the renal artery clip, the blood pressure fall was less when the inner renal papilla was ablated than when it was intact, although plasma renin concentration and Na balance were similar. The final blood pressure was similar to that observed in normal rats treated with 2-bromoethylamine vs. their respective controls. The inner renal medulla apparently produces a vasodepressor that influences blood pressure in normal rats, and also lowers blood pressure when 2-kidney, 1-clip hypertension is reversed surgically.