The Effects of 250-Kv X-Rays on the Dog's Pancreas: Morphological and Functional Changes

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Abstract
Pancreas of 9 dogs was surgically isolated to the right side of the abdomen and irradiated with a total dose of 4500 to 5000 rads fractionated over 30 days. At the end of irradiation and at 1 month, 2 months, and 5 months after irradiation, the histological changes demonstrated a progressive interstitial fibrosis and scarring which distorted the regular architecture. The acini were separated by fibrosis but were morphologically intact. The islets showed no histological change. Beta and alpha cells were present One dog with a modified total pancreatic fistula survived 2 weeks after receiving a tissue dose of 4500 rads to the pancreas fractioned over 24 days. The total 24-hr, secretory volume and the secretory volumes after secretin and Mecholyl stimulation were unchanged during and after irradiation. The serum and pancreatic secretion electrolytes, fasting blood sugars, and glucose tolerance determinations were within normal limits. However, the elevated serum amylase decreased, whereas the concentration of amylase in the pancreatic secretion increased. These studies are consistent with the morphological findings, indicating that the function of the pancreas is not markedly altered by the dose and time schedule of irradiation used in this study.

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