THE MOUSE PALE EAR PIGMENT MUTANT AS A POSSIBLE ANIMAL-MODEL FOR HUMAN-PLATELET STORAGE POOL DEFICIENCY

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (1) , 38-43
Abstract
The mouse pigment mutant pale ear, ep/ep, which has a defect in kidney lysosomal enzyme secretion, had prolonged bleeding on experimental injury. Platelet counts and platelet protein did not differ from normal. There was a deficiency in the platelet dense granule contents, serotonin, ATP and ADP. A marked reduction of platelet dense granules was observed by EM. Apparently pale ear is a useful animal model in the study of platelet storage pool disease. Studies on this mutant and other pigment mutants have established that 1 gene can regulate at least 3 subcellular organelles, including the melanosome, the lysosome and the platelet dense granule.