The Bacteriostatic Action of Benzoic and Salicylic Acids. IV. The Effect on Oxidation of TCA Cycle Intermediates, Lactate, and Gluconate.

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Abstract
Resting cells of Proteus vulgaris oxidize succinate, fumarate, malate, and oxalacetate at similar rates; whereas, a-ketoglutarate is attacked more slowly. Exogenous citrate is not metabolized at pH 6.0 by resting cells. The rate of oxidation of the dicarboxylic acids involved in the TCA cycle is inhibited to a varying extent by benzoic and salicylic acids according to the conditions prevailing during growth of the cells. The total amount of O2 consumed per mole of substrate is somewhat increased by the inhibitors studied. The oxidation of lactate is not blocked at the acetate level by benzoic and salicylic acids. Streptomycin, at concentrations arresting growth, does not effect the oxidation of pyruvate by resting cells of P. vulgaris.