Diverging effects of chemotactic serum peptides and synthetic f-Met-Leu-Phe on neutrophil locomotion and adhesion (Abstract)

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Abstract
The chemotactic serum peptides CAT 1.6.1. and C5adesArg induced marked directional locomotion over a wide concentration range. They had, however, no significant effects on random locomotion and adhesion of human neutrophils. In contrast, f-Met-Leu-Phe produced marked negative chemokinetic effects and its capacity to induce directional locomotion was more limited with respect to magnitude and concentration range. Migration inhibition as induced by f-Met-Leu-Phe was related to its dose-dependent effects on spreading and cell adhesion. The results suggested that chemotactic serum peptides are more suitable than f-Met-Leu-Phe to study reactions which are specifically related to Chemotaxis, at least under the test conditions used. Keywords Public Health Cell Adhesion Human Neutrophil Press Limited Wide Concentration Range These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.