Interchain and Intrachain Disulfide Bridges of a Human Immunoglobulin M: Detection of a Unique Fragment
- 1 July 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (7) , 1547-1551
- https://doi.org/10.1073/pnas.68.7.1547
Abstract
Studies of the amino acid sequences around half-cystine residues in an immunoglobulin M have revealed an unexpectedly high number. At least 14 different sequences were found in the mu chain (V(HIII) subclass). Four of these were involved in interchain disulfide bridges and at least 10 in intrachain bridges. Five came from the kappa chain (kappa(III) subclass, Inv b). Several others, although having a high degree of homology, were not identical with those of either the mu or kappa chains. These results support the concept of an additional fragment in gammaM molecules, although its function and localization remain to be determined.Keywords
This publication has 19 references indexed in Scilit:
- Structure of the Hinge Region of the Mu Heavy Chain of Human IgM ImmunoglobulinsScience, 1971
- Immunoglobulin M and Secretory Immunoglobulin A: Presence of a Common Polypeptide Chain Different from Light ChainsScience, 1971
- Novel Subunit in Secretory IgANature, 1970
- Macroglobulin Structure: Variable Sequence of Light and Heavy ChainsScience, 1970
- Evidence for C-terminal intra-subunit disulphide bridges between immunoglobulin-M heavy chainsFEBS Letters, 1970
- Structure and evolution of immunoglobulinsProgress in Biophysics and Molecular Biology, 1970
- Macroglobulin Structure: Homology of Mu and Gamma Heavy Chains of Human ImmunoglobulinsScience, 1969
- Immunoglobulins: Structural Studies of Immunoglobulin GNature, 1969
- Variations in the S—S bridges of immunoglobins G: Interchain disulphide bridges of γG3 myeloma proteinsJournal of Molecular Biology, 1968
- Inter Heavy–Light Chain Disulphide Bridge in Immune GlobulinsNature, 1967