Cystitis Associated with Chlamydia IInfection of the Genital Tract in Male Guinea Pigs

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Abstract
Male guinea pigs were infected with the chlamydial agent of guinea pig inclusion conjunctivitis (GPIC) by intraurethral injection of chlamydiae or by placement of a drop of chlamydial suspension on the meatus of the extruded penis. Transient urethritis and cystis were observed in animals infected by either method. The production of cystitis by the drop-on technique indicated that chlamydiae are able to ascend the urethra and that the bladder may be a target organ of chlamydial infection. When infected animals were immunosuppressed by cyclophosphamide, the number of guinea pigs with cystitis increased; chlamydiae were detected in the bladder for as long as 50 days after infection. GPIC was not detected in the bladders of untreated animals after day 18.