REDUCTION OF URINE OXALATE DURING LONG-TERM THIAZIDE THERAPY IN PATIENTS WITH CALCIUM UROLITHIASIS
- 1 January 1980
- journal article
- research article
- Vol. 18 (2) , 170-173
Abstract
Urinary oxalate was measured by the method of Hallson and Rose before and during long-term thiazide therapy in 49 patients with recurrent urolithiasis. Urinary oxalate excretion in normal men and women on their usual diets was 38.8 .+-. 10.3 mg/day (mean .+-. SD) and in patients with calcific renal calculi was 45.9 .+-. 14.3 mg/day. Hydrochlorothiazide produced a significant decrease in urinary oxalate excretion in patients treated for more than 12 mo. (33 .+-. 10.6 mg/day). The thiazide-induced reduction of urinary oxalate excretion may be related to reduced intestinal Ca absorption which was shown during chronic thiazide therapy and may not be evident until 12 or more months of thiazide administration.This publication has 8 references indexed in Scilit:
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