STUDIES ON SCHIZOPHRENIA IV

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Abstract
With a modification of the Adamkiewicz-Hopkins-Cole procedure on urine, positive reactions were obtained in most idiopathic schizophrenics and in a number of organic psychotic and non-psychotic conditions. It is not positive in normals, nor in various neurotic and cyclothymic patients when they are physically healthy. A positive reaction is characteristic of,but not specific for, idiopathic schizophrenia. The positive reaction is essentially independent of an increase of indican in the urine. The positive reaction is probably due to a disturbance of tryptophan metabolism, possibly combined with the presence of catalysts in the urine. The exact nature of the substance or substances producing a positive reaction is unknown.