Cows' milk protein intolerance: a possible association with gastroenteritis, lactose intolerance, and IgA deficiency.
- 19 June 1976
- Vol. 1 (6024) , 1501-1504
- https://doi.org/10.1136/bmj.1.6024.1501
Abstract
Twenty-five children with cows' milk protein intolerance were studied. Twenty had presented with an illness clinically indistinguishable from infantile gastroenteritis; an enteropathogenic Escherichia coli was isolated from the stools in two children, and in six another member of the family simultaneously developed acute diarrhoea and vomiting. Twenty-three children had lactose intolerance secondary to cows' milk protein intolerance. Eight out of 20 children were found to be partially IgA deficient. An acute attack of gastroenteritis, in damaging the small mucosa, may act as a triggering mechanism in cows' milk protein intolerance, and a deficiency in IgA may be a predisposing factor in so far as it allows the patient to become sensitised to foreign protein.Keywords
This publication has 6 references indexed in Scilit:
- TRANSIENT IgA DEFICIENCY AND PATHOGENESIS OF INFANTILE ATOPYThe Lancet, 1973
- Duodenal mucosal damage in 31 infants with gastroenteritisArchives of Disease in Childhood, 1973
- CLINICAL AND IMMUNOLOGICAL ASPECTS OF MILK PROTEIN INTOLERANCEJournal of Paediatrics and Child Health, 1972
- Cow's Milk Induced Malabsorption as a Precursor of Gluten IntoleranceActa Paediatrica, 1965
- Hereditary Sucrose Intolerance: Levels of Sucrase Activity in Jejunal MucosaArchives of Disease in Childhood, 1964
- THE GASTROINTESTINAL ABSORPTION OF UNALTERED PROTEIN IN NORMAL INFANTS AND IN INFANTS RECOVERING FROM DIARRHEAPediatrics, 1955