Contributions caryologiques sur la régénération du parenchyme hépatique au cours de l’atteinte toxique expérimentale

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Abstract
The nuclear changes of rat liver cells are investigated by means of direct karyometric measurements during several stages of thioacetamide intoxication. It was shown that the nuclear volumes undergo phasic changes which are in close topographical and chronological relationship to the so-called bile duct proliferations. Before the beginning of bile duct-like proliferations (between 30 and 40 days of continuous administration) the nuclear volumes of liver cells located near the central veins exhibit a gradual enlargement, whereas in subsequent stages they show a striking variability induced mainly by the reapparition of small liver cell nuclei. The results indicate the presence of proliferative processes. It is suggested that the latter are of amitotic origin and that the initial enlargement of liver cell nuclei reflect a process of polyploidisation. The observations are discussed in relation to the liver cell regeneration and the origin of ductular-like cell proliferation.