Potentiation of Pressor Effects of Noradrenaline and Potassium Ions in the Rat Mesenteric Arteries by Physiological Concentrations of Angiotensin II: Effects of Prostaglandin E2 and Cortisol

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Abstract
In the perfused rat mesenteric vascular bed, the effects of angiotensin II, cortisol and prostaglandin E2 on the vascular responses to noradrenaline [norepinephrine] or KCl were studied. Angiotensin II in subpressor concentrations potentiated the vasoconstrictor response to noradrenaline and KCl. This effect of angiotensin II was inhibited in the presence of indomethacin and prostaglandin E2. Cortisol in physiological concentrations inhibited the potentiating effect of angiotensin II. Prostaglandin E2 enhanced the vasoconstrictor response to noradrenaline. This effect was not abolished by cortisol. Some actions of angiotensin II and cortisol in vivo are probably mediated by the regulation of prostaglandin synthesis or release.