INTERACTION OF ANGIOTENSIN-II WITH NORADRENALINE AND OTHER SPASMOGENS ON RABBIT ISOLATED AORTIC STRIPS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 219  (1) , 29-44
Abstract
Angiotensin II in sub-contractor concentrations enhanced the contractions of rabbit isolated aortic strips to noradrenaline, KCl, histamine, acetylcholine, isoprenaline and 5HT [5-hydroxytryptamine]. The potentiation of noradrenaline responses by angiotensin II was independent of any effect of angiotensin II on neuronal uptake of noradrenaline. The sensitization of this tissue to spasmogens induced by angiotensin II occurred in reserpine-treated preparations and in normal tissues suspended in Ca-free bathing medium. Procedures which abolished the transfer of Na+ across membranes such as substitution of fructose for glucose in the bathing medium, absence of K ions or treatment with ouabain each abolished the non-specific sensitization. Angiotensin II may cause a non-specific sensitization of this tissue by inhibiting Na transfer across the cell membrane.